Rugby High Potency Arthritis Pain Relieving Cream, 2 oz Each (Pack of 4) - This maximum strength cream uses the natural power and heat of the chili pepper to relieve even your toughest muscle and joint pains. It works by blocking your body's pain messenger, Substance P. Found in nerve cells, Substance P is responsible for transmitting pain signals to your brain. This cream by Rugby Labs blocks it, and the pain. This maximum strength cream uses the natural power and heat of the chili pepper to relieve even your toughest muscle and joint pains. It works by blocking your body's pain messenger, Substance P is responsible for transmitting pain signals to your brain. This cream by Rugby Labs blocks it, and the pain. Arthritis creams help relieve joint pain when applied to the skin. They can provide short-term but effective relief. These creams tend to work best on joints that are close to the surface of the skin, such as the joints in the hands or knees. Mitting pain signals to your brain. This cream by Rugby Labs blocks it, and the pain. Directions: Adults and children 18 years of age and older: Apply a thin film of cream to the affected area and gently rub in until fully absorbed. Unless treating hands, wash hands thoroughly with soap and water immediately after application. For best results, apply 3 to 4 times daily. Children under 18 years: ask a doctor. Other information: Store at room temperature 15° - 30°C (59°F – 86°F).